%0 Journal Article
%T EXPERIMENTAL STUDY OF APOPTOSIS AND ITS MOLECULAR MECHANISMS OF NASOPHARYNGEAL CARCINOMA CELL INDUCED BY MILLIMETER WAVE IRRADIATION<br>毫米波辐照诱导鼻咽癌细胞凋亡及分子机制的实验研究
%A 王艳萍
%A 袁淑兰
%J 红外与毫米波学报
%D 2001
%I Science Press
%X The effect of millimeter wave radiation on the nasopharyngeal carcinoma cell line CNE 1 cell proliferation and apoptosis and the expression of related genes was studied by using cell count, light microscopy and the flow cytometry (FCM). By millimeter wave radiation with 1 mW/cm 2 power density at frequency 42.2GHz and wave length 7.1mm on CNE 1 cells for a duration of 30min/day for 4 days, cell proliferation and cloning formation were inhibited markedly, and cell apoptosis was induced. FCM also revealed that the inhibiting effect of CNE 1 proliferation by millimeter wave was probably associated with the up regulation of P21 and the down regulation of Cyclin D 1. The molecular mechanism of apoptosis inducing may be p53 independent and c Myc dependent. The up regulation of c Myc and Fas and down regulation of Bcl 2 may play an important role in the process of apoptosis.
%K millimeter wave
%K nasopharyngeal carcinoma cell line
%K apoptosis
%K gene expression<br>毫米波
%K 鼻咽癌细胞株
%K 凋亡
%K 基因表达
%K 分子机制
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=1319827C0C74AAE8D654BEA21B7F54D3&jid=D3B4F771D1A06062008B4D0A2EF05996&aid=07C70F1FD598C4EA&yid=14E7EF987E4155E6&vid=A04140E723CB732E&iid=E158A972A605785F&sid=E2B9962CCD971A0D&eid=11CEECA6DA9E4AC5&journal_id=1001-9014&journal_name=红外与毫米波学报&referenced_num=0&reference_num=14