%0 Journal Article
%T Effects of quinolones on activity of hepatic drug-metabolizing enzymes in Paralichthys olivaceus<br>喹诺酮类药物对牙鲆肝药物代谢酶活性的影响
%A HAN Hua
%A LI Jian
%A Li Ji-tao
%A HAN Xian-qin
%A Chen Ping
%A <br>韩华
%A 李健
%A 李吉涛
%A 韩现芹
%A 陈萍
%J 海洋科学
%D 2009
%I 
%X In order to observe the difference of effects of quinolones on the activity of drug-metabolism(cytochrome P-450),we studied the effects of quinolones(FQ)on the activities of APND,ERND and EROD in the liver of flounders(Paralichthys olivaceus).The results showed that the activities of APND,ERND and EROD in the S_9 mix were inhibited by the three kinds of quinolones on the different degrees,where enrofloxacin and norfloxacin treated groups had a very significant decrease on the activities of APND,ERND and EROD compared to the control group(P＜0.01),while flumequine treated group only decreased the activity of EROD very significantly(P＜0.01),and had a significant decrease on the activities of APND and ERND.
%K Paralichthys olivaceus
%K Cytochrome P450 enzymes
%K quinolones<br>牙鲆(Paralichthys
%K olivaceus)
%K 细胞色素P450
%K 喹诺酮类药物
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=E62459D214FD64A3C8082E4ED1ABABED5711027BBBDDD35B&cid=2D9C75573FA3E416&jid=DFE7B94EB76B8F26135C9890832CEF6A&aid=8E69E67F04ED09CF518A86EEBFEBD7F9&yid=DE12191FBD62783C&vid=27746BCEEE58E9DC&iid=708DD6B15D2464E8&sid=B6DA1AC076E37400&eid=318E4CC20AED4940&journal_id=1000-3096&journal_name=海洋科学&referenced_num=1&reference_num=36