%0 Journal Article
%T Changes of nitric oxide and nitric oxide synthetase in rat liver after exposure to environmental mercury<br>环境汞污染暴露下大鼠肝中一氧化氮及一氧化氮合酶的变化
%A JI Xiuling
%A WANG Wenhu
%A CHENG Jinping
%A ZHAO Xiaoxiang
%A ZHUANG Huisheng
%A <br>冀秀玲
%A 王文华
%A 程金平
%A 赵晓祥
%A 庄惠生
%J 环境科学学报
%D 2007
%I 
%X In order to survey the potential health risk of environmental exposure to mercury, Sprague-Dawley rats were reared on wastewater-contaminated rice from the Qingzhen area. Changes of nitric oxide (NO) and nitric oxide synthetase (NOS) in rat liver were examined after different exposure periods. The results showed that, compared with the controls, levels of NO and NOS in rat liver significantly increased after 7 days exposure to mercury-contaminated rice (p<0.05). However, when compared with the long-term exposure group, the content of NO in rat liver changed only slightly during the 7 to 30 day exposure periods. Element correlation analysis showed high correlations of mercury and selenium in the liver of rats fed with Qingzhen rice (r=0.9426), suggesting that the coexisting selenium in rice reduced the negative effects on mercury toxicity. After 90 days exposure, NO in rat liver increased 200%, and the peroxide MDA in rat liver also increased significantly (p<0.05), indicating aggravated oxidative status in rat liver after long-term exposure to environmental mercury.
%K environmental mercury
%K nitric oxide
%K nitric oxide synthetase<br>环境汞污染
%K 一氧化氮
%K 一氧化氮合酶
%K 环境汞污染
%K 暴露
%K 大鼠肝
%K 及一氧化氮合酶
%K 变化
%K mercury
%K environmental
%K exposure
%K rat
%K liver
%K nitric
%K oxide
%K synthetase
%K 氧化损伤
%K 机体
%K 脂质过氧化产物丙二醛
%K 对照组
%K 影响
%K 毒性作用
%K 元素对
%K 关系
%K 相关
%K 元素含量
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=815415A8B6CEB92631471EE98E6A97CC&yid=A732AF04DDA03BB3&vid=DB817633AA4F79B9&iid=B31275AF3241DB2D&sid=6A2E9D0F5619615A&eid=5CC11A326E54A79A&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=0&reference_num=22