%0 Journal Article
%T Oxidation damage of sulfur dioxide on various organs of mice<br>二氧化硫对小鼠不同组织器官的氧化损伤作用
%A MENG Ziqiang
%A ZHANG Bo
%A QIN Guohua
%A <br>孟紫强
%A 张波
%A 秦国华
%J 环境科学学报
%D 2001
%I 
%X The mice were treated by SO2 inhalation for 4 h/day × 7 days, and then activities of Cu,Zn superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), levels of reduced glutathione (GSH) and lipid peroxidation, of various organs (brain, lung, heart, liver, spleen, and kidney) were measured. The results showed that (1) SO2 inhalation decreased the activities of SOD and GSH-Px, also decreased levels of GSH, but increased levels of lipid peroxidation in all mouse organs tested; (2) levels of oxidation damage caused by SO2 were different in various organs, especially oxidation damages of brains, hearts, livers and lungs of mice tested were more serious; (3) Some sex differences were also found. It was suggested that (1) The primary mechanism of toxicological role on mammalian cells by SO2 exposure may be that oxidation damages of lipid and other biomacromolecule are caused by SO2 producing reactive oxygen species; (2) SO2 is a systemic toxin, some damages and diseases of various organs and tissues may be caused by SO2 exposure.
%K sulfur dioxide
%K oxidation damage
%K lipid peroxidation
%K systemic toxin
%K mouse<br>二氧化硫
%K 氧化损伤
%K 脂质过氧化作用
%K 全身性毒物
%K 小鼠
%K 组织器官
%K 大气污染
%K 生物监测
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=F0766F261298D195&yid=14E7EF987E4155E6&vid=659D3B06EBF534A7&iid=B31275AF3241DB2D&sid=B5D9C773C430C13C&eid=1F7317C17A9AF4FA&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=57&reference_num=7