%0 Journal Article
%T Effect of 12-dimethylbenz(a)athrancene and benzo(a)pyrene on metallothionein expression and lipid peroxidation in mouse liver<br>二甲基苯蒽和苯并(a)芘对小鼠肝脏金属硫蛋白及氧化损伤的诱导作用
%A ZHANG Baoxu
%A RUAN Ming
%A QIU Feichan
%A JIA Fenglan
%A WEI Xuetao
%A JIANG Jianjun
%A SHANG Lanqin
%A <br>张宝旭
%A 阮明
%A 邱飞婵
%A 贾凤兰
%A 魏雪涛
%A 蒋建军
%A 尚兰琴
%J 环境科学学报
%D 2002
%I 
%X To study the induction of metallothionein (MT) and lipid peroxidation by two polycyclic aromatic hydrocarbons (PAHs), 7,12 dimethylbenza]athrancene (DMBA) and benzoa]pyrene (BaP) in mice liver. Male mice were treated with DMBA or BaP i.p. at the dose of 50?mg/kg body weight for 0, 24, 48, 72 and 144?h, respectively. Liver MT was measured by the cadmium/hemoglobin saturation assay. Lipid peroxidation product (malondialdehyde, MDA) was measured as thiobarbituric acid reactive substances. After DMBA or BaP treatment, mice liver weight, MT and MDA increased in amount. Liver boby weight ratio increased significantly in a time dependent manner. MT was significantly induced vs control after 24?h with PAHs treatment. Liver MDA level was elevated one fold after 24?h treatment. Liver MT has been induced by PAHs. The correlation between MT expression and MDA level suggest that MT may be related with oxidative stress caused by PAHs.
%K metallothionein
%K 7
%K 12
%K dimethylbenz[a]athrancene
%K benzo[a]pyrene
%K lipid peroxidation<br>肝脏
%K 氧化损伤
%K 金属硫蛋白
%K 二甲基苯蒽
%K 苯并（a）芘
%K 脂质过氧化
%K 致癌物质
%K 环境污染物
%K 毒性机理
%K 多环芳烃
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=FF1C58EE6C32EE3B&yid=C3ACC247184A22C1&vid=BC12EA701C895178&iid=B31275AF3241DB2D&sid=231F9A307C169827&eid=70081086C74F4110&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=3&reference_num=12