%0 Journal Article
%T A COMPARATIVE STUDY ON CARCINOGENIC ACTIVITY OF PBNA AND PANA IN UNILATERALLY NEPHRECTOMIZED TA-l MICE<br>PBNA及其同分异构体PANA在TA-1系小鼠切除一侧肾脏后的致癌性研究
%A Wang D
%A Zeng Ruowang
%A Wang Hengwen
%A <br>王达
%A 曾若望
%A 王蘅文
%J 环境科学学报
%D 1983
%I 
%X Repeated subcutaneous injections of DMSO-dissolved technical or chemically pure PBNA and its corresponding isomer PANA all induced in male young adult TA-1 mice significantly higher incidence of malignancy than controls. Total doses given amounted to 304-328mg. At the end of the 9th month malignant tumors were induced in all of four groups. Incidence of hemangiosarcoma of the kidney was as follows: nephrectomy + technical PBNA: 76.2%; nephrectomy+pure PBNA: 47.1%; nephrectomy+technical PANA: 100%; nephrectomy+pure PANA:75%. More pulmonary carcinoma were induced in both PBNA groups than in PANA groups. Technical PBNA in DMSO injected repeatedly to TA-1 mice induced pulmonary carcinoma in 21.1% of mice. Technical PANA induced hemangiosarcoma of the kidney in 36.8% of mice. It was shown that both technical PBNA (neoZone D) and technical PANA (neozone A) were carcinogenic to TA-1 mice with different orgnotropism while previous unilateral nephrectomy increased the susceptibility of the another kidney to the induction of hemangiosacoma.
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=FA5AD51E70AF0A41C0699BE983B95E4A&yid=A7F20A391020FDEE&vid=38B194292C032A66&iid=38B194292C032A66&sid=30897FA31CA3354D&eid=4FE459D71E3BF8EB&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=0&reference_num=0