%0 Journal Article
%T Experimental study of the DNA damage induced by formaldehyde<br>甲醛致核酸损伤作用的实验研究
%A XI Zhuge
%A CHAO Fuhuan
%A YANG Danfeng
%A SUN Yongmei
%A LI Guanxian
%A ZHAN Huashan
%A ZHAN Wei
%A YANG Yuhua
%A LIU Huanliang
%A <br>袭著革
%A 晁福寰
%A 杨丹凤
%A 孙咏梅
%A 李官贤
%A 张华山
%A 张伟
%A 杨玉花
%A 刘焕亮
%J 环境科学学报
%D 2004
%I 
%X The DNA damages induced by the typical environmental pollutant formaldehyde was studied with single cell gel electrophoresis(SCGE) and high performance liquid chromatography with electrochemical detection(HPLC-EC). The results showed that formaldehyde could not only cause DNA strand breakage but also DNA DNA, DNA protein crosslinks of lymphocytes of human peripheral blood. The reaction of formaldehyde with DNA in vitro is weak, but the oxidative ability is enhanced and the reaction could produce a number of 8-OHdG adducts mediated by the Fe2+. The animal experiment showed that formaldehyde could cause the oxidative DNA damage of rat lung tissues, which suggested that formaldehyde have the stronger genotoxicity.
%K 甲醛
%K 核酸损伤
%K DNA链断裂
%K DNADNA交联
%K DNA蛋白质交联
%K 8羟基脱氧鸟苷
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=00BC326BE9A573BE&yid=D0E58B75BFD8E51C&vid=B91E8C6D6FE990DB&iid=E158A972A605785F&sid=4D0B71A09FA5A2A5&eid=D7F3FD6D87AEF622&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=12&reference_num=6