%0 Journal Article
%T EFFECTS OF CADMIUM ON THE CONJUGATION OF RAT KIDNEY CORTEX<br>镉对大鼠肾皮质结合反应的影响
%A Ding Hanping
%A Liu Yugu
%A <br>丁汉平
%A 刘毓谷
%J 环境科学学报
%D 1993
%I 
%X The effects of cadmium on two kinds of conjugation reaction in rat kidney cortex in vivo and in vitro were studied. One was kidney cortex microsomal glutathione S-transferase (GST), and the other was glucuronic acid(GA)conjugation in isolated kidney cortex cells. It was found: l). Cadmium could inhibit kidney cortex microsomal GST activities in vitro under Cd2+ concentration from 107mol/L to 103mol/L;2). GST activity was " not markedly changed in vivo after the ip injection of cadmium(2.4mg(kg·d)-l for 3 days); 3). When CdCl2 was administered to rats in vivo by ip injection in the same way it could markedly decrease the conjugation of glucuronic acid with 7-hydroxycoumarin in isolated rat kidney cortex cells; and 4).Lower Cd2+concentration (10-7mol/L)could increase the conjugation of GA with 7-HC in isolated rat kidney cortex cells in vitro, but higher Cd2+concentrations(10-6mol/L-10-2mol/L)could markedly decrease the conjugation of GA with 7-HC in vitro.
%K Cadmium
%K Kidney cortex microsomes
%K Conjugation
%K Isolated kidney proximal tubule cells<br>镉
%K 肾皮质
%K 微粒体
%K 结合反应
%K 大鼠
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=670CFF67F8157F868C00783CEE990925&yid=D418FDC97F7C2EBA&vid=FC0714F8D2EB605D&iid=38B194292C032A66&sid=4C2B9916B58305BE&eid=23410D0BDB501DF5&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=0&reference_num=3