%0 Journal Article
%T Study on oxidation stress effects of PM2.5 on cardiovascular endothelium cells<br>大气细颗粒物(PM2.5)对心血管内皮细胞NOS的影响
%A ZHANG Yunhui
%A DING Jiawei
%A CAO Shen
%A KAN Haidong
%A <br>张蕴晖
%A 丁佳玮
%A 曹慎
%A 阚海东
%J 环境科学学报
%D 2006
%I 
%X Exposure to PM2.5 was found to be significantly correlated with the increasing cardiovascular disease mortality in recent epidemiological studies. But there have had little experimental studies to explore the potential mechanism of this adverse effect of PM2.5 until now. In this study, cardiovascular endothelium cells were treated by PM2.5 collected from urban area of Shanghai, with doses of 0.01,0.05,0.2 and 1 mg·mL-1. Parameters (including activities of total NOS, iNOS and cNOS) reflecting the oxidation stress damage were measured. Results showed that the activities of total NOS and iNOS in cardiovascular endothelium cells treated with 0.2 mg mL-1 PM2.5 were significantly higher than those in control cells. Dose-response relationship was established in this study. These results meant that PM2.5 could induce the activity of iNOS in cardiovascular cells and the oxidation stress damage might be one of the mechanisms of PM2.5 effect on cardiovascular system.
%K PM2
%K 5
%K cardiovascular toxicity
%K NOS<br>PM2.5
%K 心血管毒性
%K 一氧化氮合酶
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=03A55E61A8750ACAC6AF81EF9E2AC838&aid=9ECAB69A1E78006C&yid=37904DC365DD7266&vid=96C778EE049EE47D&iid=CA4FD0336C81A37A&sid=E22B6B8FE86DD8F9&eid=769BD58726D66E7D&journal_id=0253-2468&journal_name=环境科学学报&referenced_num=0&reference_num=11