%0 Journal Article
%T A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942
%A Hiroyuki Yamazaki
%A Henki Rotinsulu
%A Tsuyoshi Kaneko
%A Kazuki Murakami
%A Hiromu Fujiwara
%A Kazuyo Ukai
%A Michio Namikoshi
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10122691
%X 1-Hydroxy-10-methoxy-dibenz[ b, e]oxepin-6,11-dione ( 1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin ( 2) and globosuxanthone A ( 3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including 1H¨C 1H COSY, HMQC and HMBC spectra). Dibenz[ b, e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays.
%K dibenzooxepine derivative
%K 1-hydroxy-10-methoxy-dibenz[b
%K e]oxepin-6
%K 11-dione
%K marine-derived fungus
%K fungal metabolites
%U http://www.mdpi.com/1660-3397/10/12/2691