%0 Journal Article
%T Briacavatolides A¨CC, New Briaranes from the Taiwanese Octocoral Briareum excavatum
%A Tsun-Tai Yeh
%A Shang-Kwei Wang
%A Chang-Feng Dai
%A Chang-Yih Duh
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10051019
%X In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A¨CC ( 1¨C 3) as well as two known briaranes, briaexcavatolide U ( 4) and briaexcavatin L ( 5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1¨C 5 and their cytotoxicity against selected cancer cell lines were evaluated.
%K Briareum excavatum
%K briarane-type diterpenoid
%K cytotoxicity
%K anti-HCMV
%U http://www.mdpi.com/1660-3397/10/5/1019