%0 Journal Article
%T Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus
%A Zhuang Han
%A Ying Xu
%A Oliver McConnell
%A Lingli Liu
%A Yongxin Li
%A Shuhua Qi
%A Xiangzhong Huang
%A Peiyuan Qian
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10030668
%X Two new antimycin A analogues, antimycin B1 and B2 ( 1¨C 2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 ¦Ìg/mL, respectively.
%K marine-derived actinomycete
%K Streptomyces lusitanus
%K antibacterial
%K antimycin B
%U http://www.mdpi.com/1660-3397/10/3/668