%0 Journal Article
%T Subchronic toxic effects of fish muscle-bound MCLR<br>鱼肉结合态MCLR的亚慢性毒性研究
%A Yang Fan
%A Xiao Bang-ding
%A Chen Xiao-guo
%A Wu Xing-qiang
%A Liu Min
%A <br>Yang F
%A Xiao BD
%A Chen XG
%A Wu XQ
%A Liu M
%J 环境科学
%D 2007
%I 
%X Subchronic oral gavage toxicity of MCLR in water and in fish muscle was examined in male Balb/C mice for 13 weeks to assess the safety of aquatic products. The results showed that the liver coefficient (p < 0.05), the activities of ALT and AST (p < 0.01) increased significantly and distinct centrilobular to midzonal hepatucellular occurred after oral gavage of dissolved MCLR at a dose of 68.75 microg/kg (body weight), but neither influence on the activities of BUN and Cr nor histological changes on kidney were observed at any time point. In contrast, the administration of fish muscle-bound MCLR at the same dose resulted in no obvious subchronic toxicity in mice, except that the increase of liver coefficient (p < 0.05) and the activity of ALT (p < 0.01) can be observed only at the first week. It was concluded that the toxicity of fish muscle-bound MCLR was much lower than that of dissolved MCLR.
%K microcystin
%K aquatic products
%K subchronic
%K toxicity<br>微囊藻毒素
%K 水产品
%K 亚慢性
%K 毒性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=64CD0AA99DD39F69401C615B85F123EF&aid=1747E9FE84DCFCFFF50FB6BA6F0587F5&yid=A732AF04DDA03BB3&vid=D3E34374A0D77D7F&iid=59906B3B2830C2C5&sid=72987ABB302603E3&eid=B55917F5071FEB5E&journal_id=0250-3301&journal_name=环境科学&referenced_num=0&reference_num=28