%0 Journal Article
%T Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata
%A Soon-Hye Park
%A Jae-Hyoung Song
%A Taejung Kim
%A Woon-Seob Shin
%A Gab Man Park
%A Seokjoon Lee
%A Young-Joo Kim
%A Pilju Choi
%A Heejin Kim
%A Hui-Seong Kim
%A Dur-Han Kwon
%A Hwa Jung Choi
%A Jungyeob Ham
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10102222
%X An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol ( 1) and five polybromocatechols ( 2¨C 6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC 50) of 2.50 ¦Ìg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC 50 of 7.11 ¦Ìg/mL, and anti-HRV3 activity, with an IC 50 of 4.69 ¦Ìg/mL, without demonstrable cytotoxicity at a concentration of 20 ¦Ìg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.
%K Neorhodomela aculeate
%K red alga
%K polybromocatechol compounds
%K antiviral activity
%K human rhinovirus
%U http://www.mdpi.com/1660-3397/10/10/2222