%0 Journal Article
%T BIOAVAILABILITY AND BIOEQUIVALENCE OF ALGAL POLYSACCHARIDE CAPSULES IN HUMAN<br>海藻多糖植物空心胶囊体内生物利用度与生物等效性研究
%A LI Ting
%A WU Pei
%A HAN Li-Jun
%A LI Jing
%A YUAN Yi
%A MA Lin
%A <br>李婷
%A 吴佩
%A 韩丽君
%A 李敬
%A 袁毅
%A 马霖
%J 海洋与湖沼
%D 2010
%I 
%X Capsules are used to encapsulate drugs. Consequently, the quality of the capsule shells is crucial for the bioavailability of the encapsulated drugs. Our laboratory developed a new plant-based capsule shell called Algal Polysaccharide Vegetable Capsule (APPC). It was composed of algal polysaccharide and cellulose. Studies on the bioavailability and bioequivalence of three types of capsules (APPC, Qualicaps, and gelatin) were conducted. Ibuprofen was adopted as model drug, and its plasma concentrations of 12 healthy volunteers were determined by high performance liquid chromatography (HPLC). Pharmacokinetic parameters are calculated on the basis of plasma concentrations with the software DAS 2.0, and the bioavailability and bioequivalence of the three types of capsules were evaluated. The aim of this paper was to compare the absorption of the drug in the capsules of APPC, Qualicaps and gelatin. The results showed that the substitution of gelatin capsules with algal polysaccharide vegetable capsules would not affect the in vivo drug absorption. Algal polysaccharide capsule met the criteria of bioequivalence with Qualicaps (relative bioavailability of 94.9%) and gelatin capsules (relative bioavailability of 97.5%).
%K Algal polysaccharide vacant capsule
%K Japanese Qualicaps vegetable vacant capsule
%K Gelatin vacant capsule
%K Bioavailability
%K Bioequivalence
%K Ibuprofen capsule<br>海藻多糖植物空心胶囊
%K 日本
%K Qualicaps
%K 植物空心胶囊
%K 明胶空心胶囊
%K 生物利用度
%K 生物等效性
%K 布洛芬胶囊剂
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=E62459D214FD64A3C8082E4ED1ABABED5711027BBBDDD35B&cid=2D9C75573FA3E416&jid=10F18692CD69EACA2DF7FC109993D35C&aid=FC44B8D56C35758763422AEFFA470E0F&yid=140ECF96957D60B2&vid=2001E0D53B7B80EC&iid=B31275AF3241DB2D&sid=4AA5FA7F666BDD0A&eid=2D207DE75533FA7E&journal_id=0029-814X&journal_name=海洋与湖沼&referenced_num=0&reference_num=0