%0 Journal Article
%T Two New Tryptamine Derivatives, Leptoclinidamide and (-)-Leptoclinidamine B, from an Indonesian Ascidian Leptoclinides dubius
%A Hiroyuki Yamazaki
%A Defny S. Wewengkang
%A Teruaki Nishikawa
%A Henki Rotinsulu
%A Remy E. P. Mangindaan
%A Michio Namikoshi
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10020349
%X Two new tryptamine-derived alkaloids, named as leptoclinidamide ( 1) and (-)-leptoclinidamine B ( 2), were isolated from an Indonesian ascidian Leptoclinides dubius together with C 2-¦Á-D-mannosylpyranosyl-L-tryptophan ( 3). The structure of 1 was assigned on the basis of spectroscopic data for 1 and its N-acetyl derivative ( 4). Compound 1 was an amide of tryptamine with two ¦Â-alanine units. Although the planar structure of 2 is identical to that of the known compound (+)-leptoclinidamine B ( 5), compound 2 was determined to be the enantiomer of 5 based on amino acid analysis using HPLC methods. Compounds 1 to 4 were evaluated for cytotoxicity against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma) cells, but none of the compounds showed activity.
%K leptoclinidamide
%K leptoclinidamine
%K tryptamine
%K alkaloid
%K Indonesian ascidian
%K Leptoclinides dubius
%U http://www.mdpi.com/1660-3397/10/2/349