%0 Journal Article %T Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources %A Hesham Fahmy %A Jordan K. Zjawiony %A Takao Konoshima %A Harukuni Tokuda %A Shabana Khan %A Sherief Khalifa %J Marine Drugs %D 2006 %I MDPI AG %R 10.3390/md402028 %X In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well asthe multiplicity of skin tumors per mouse compared to untreated controls.Semi-synthetic Cembranoids from Marine Sources %K Cancer chemoprevention %K Skin cancer %K Cembranoids %K Sarcophine %K Sarcophyton glaucum %U http://www.mdpi.com/1660-3397/4/2/28