%0 Journal Article
%T Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
%A Yusuke Wakuda
%A Takaaki Kubota
%A Hiroshi Shima
%A Tadashi Okada
%A Shinya Mitsuhashi
%A Naohito Aoki
%A Kunimi Kikuchi
%A Jun\'ichi Kobayashi
%J Marine Drugs
%D 2006
%I MDPI AG
%R 10.3390/md401009
%X Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
%K Protein tyrosine phosphatases
%K TCPTP
%K Inhibitors
%K Manzamenones
%U http://www.mdpi.com/1660-3397/4/1/9