%0 Journal Article
%T Isolation of Araguspongine M, a New Stereoisomer of an Araguspongine/Xestospongin alkaloid, and Dopamine from the Marine Sponge Neopetrosia exigua Collected in Palau
%A Hongwei Liu
%A Yuri Mishima
%A Takeshi Fujiwara
%A Hiroshi Nagai
%A Akira Kitazawa
%A Yuji Mine
%A Hisayoshi Kobayashi
%A Xinsheng Yao
%A Junko Yamada
%A Taiko Oda
%A Michio Namikoshi
%J Marine Drugs
%D 2004
%I MDPI AG
%R 10.3390/md204154
%X A new stereoisomer of an araguspongine/xestospongin alkaloid, named araguspongine M (1), has been isolated together with 12 known compounds, araguspongines B (2) and D (3), dopamine, three galactosyl diacylglycerols, 24-methyl cholesterol, 5,6-dihydrocholesterol, ¦Â-sitosterol, and three 5¦Á,8¦Á-epidioxy sterols (11¨C13), from the marine sponge Neopetrosia exigua (formerly Xestospongia exigua) collected in Palau. The structure of 1 was assigned on the basis of its spectral data analysis. This is the first report on the isolation of dopamine from a marine sponge. This compound may be produced by an endosymbiotic Synechococcus-like cyanobacterium. Compounds 1¨C3 and 11¨C13 showed cytotoxicity against HL-60 at IC50¡¯s of 5.5, 5.5, 5.9, 22.4, 9.5, and 9.6 ¦ÌM, respectively. The possible biosynthesis origin of the isolated metabolites is discussed.
%K Marine sponge
%K Neopetrosia exigua
%K araguspongine/xestospongin alkaloid
%K cytotoxicity
%K HL-60
%U http://www.mdpi.com/1660-3397/2/4/154