%0 Journal Article
%T Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
%A Janice R. Sufrin
%A Steven Finckbeiner
%A Colin M. Oliver
%J Marine Drugs
%D 2009
%I MDPI AG
%R 10.3390/md7030401
%X S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
%K adenosylmethionine
%K ethylene
%K polyamines
%K radical SAM
%K quorum sensing
%U http://www.mdpi.com/1660-3397/7/3/401