%0 Journal Article
%T ATRP SYNTHESIS AND SELF-ASSEMBLY BEHAVIOR OF CHITOSAN-O-PMPEGMA<br>壳聚糖-Ｏ-聚(聚乙二醇甲醚甲基丙烯酸酯)接枝共聚物的ATRP合成及其自组装研究
%A HE Yuan
%A YU Lin
%A TAN Songwei
%A JIANG Hongliang
%A TU Kehua
%A WANG Liqun
%A <br>何嫄
%A 於麟
%A 谭松巍
%A 蒋宏亮
%A 涂克华
%A 王利群
%J 高分子学报
%D 2010
%I 
%X The bromized sodium dodecyl sulfate(SDS)-chitosan(CS)complex(Br-SCC)was synthesized by conjugating 2-bromo-2-methyl propionic acid to the hydroxyl groups of SCC which was used as an organo-soluble precursor in this study.Br-SCC was used as a macromolecular ATRP initiator to polymerize methyl ether poly(ethylene glycol)methacrylate(PMPEGMA)using copper(I)bromide/bipyridine as a catalyst,yielding SCC-O-PMPEGMA.SDS was removed from the product by precipitating SCC-O-PMPEGMA solution into aqueous tris(hydroxymethyl)amine (Tris) medium.The chemical structure of the intermediate and CS-O-PMPEGMA was studied by FTIR and 1H-NMR.The substitution degree of bromobutyric acid could be modulated by bromobutyric acid/SCC feed ratio.The degree of polymerization of PMPEGMA could be controlled by varying the PMPEGMA/Br-SCC ratio.Complexation behaviors between CS-O-PMPEGMA and heparin were studied by dynamic light scattering,zeta potential analyzer and TEM.With the increase of heparin/CS molar ratio (X),there was an increase in the nanoparticle size and decrease in the zeta potential of the particles.When X was above 2,the size and the zeta potential reached a plateau stage.The ultimate size of the spherical nanoparticles was about 44 nm and the zeta potential was -8.9 mV.CS-O-PMPEGMA which could be conveniently synthesized according to the scheme proposed in this study has well-defined chemical structure.The grafting of PMPEGMA has no effect on the cationic density of the final product.In addition,the copolymers could form spherical micelles with anionic agents.The above characteristics of CS-O-PMPEGMA make it promising for tumor targeting and gene delivery.
%K 壳聚糖
%K 复合物
%K 聚乙二醇
%K 原子转移自由基聚合
%K 自组装
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=15971983683C7643EE80F1CE621DEB60&aid=56AB923F072FB7C64BD658F2C9554B08&yid=140ECF96957D60B2&iid=DF92D298D3FF1E6E&sid=547650636788ED84&eid=F52FA2254444BE97&journal_id=1000-3304&journal_name=高分子学报&referenced_num=0&reference_num=19