%0 Journal Article
%T The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
%A Shana L. Geffeney
%A C. Ruben
%J Marine Drugs
%D 2006
%I MDPI AG
%R 10.3390/md403143
%X Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.
%K neurotoxin
%K TTX
%K NaV
%K inward sodium current
%K voltage clamp
%U http://www.mdpi.com/1660-3397/4/3/143