%0 Journal Article %T Bioavailability of Metal Ions and Evolutionary Adaptation %A Rolando P. Hong Enriquez %A Trang N. Do %J Life %D 2012 %I MDPI AG %R 10.3390/life2040274 %X The evolution of life on earth has been a long process that began nearly 3,5 x 10 9 years ago. In their initial moments, evolution was mainly influenced by anaerobic environments; with the rise of O 2 and the corresponding change in bioavailability of metal ions, new mechanisms of survival were created. Here we review the relationships between ancient atmospheric conditions, metal ion bioavailability and adaptation of metals homeostasis during early evolution. A general picture linking geochemistry, biochemistry and homeostasis is supported by the reviewed literature and is further illustrated in this report using simple database searches. %K metalloproteins %K Fenton reaction %K bioavailability %K aerobic respiration %K photosynthesis %K organelle %U http://www.mdpi.com/2075-1729/2/4/274