%0 Journal Article
%T Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line
%A Taiko Oda
%A Michio Namikoshi
%A Kyoko Akano
%A Hisayoshi Kobayashi
%A Yoshio Honma
%A Tadashi Kasahara
%J Marine Drugs
%D 2005
%I MDPI AG
%R 10.3390/md302064
%X Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-¦ĘB activation at noncytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.
%K verrucarin A
%K MAP kinase
%K HL-60
%K p38-phosphorylation
%K JNKphosphorylation
%U http://www.mdpi.com/1660-3397/3/2/64