%0 Journal Article
%T An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(¦Á), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
%A Hesham Fahmy
%A Sherief I. Khalifa
%A Takao Konoshima
%A Jordan K. Zjawiony
%J Marine Drugs
%D 2004
%I MDPI AG
%R 10.3390/md201001
%X An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(¦Á), 16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin.
%K cancer chemoprevention
%K cembranoids
%K sarcophine
%K sarcophytol A
%K EBV-EA activation
%U http://www.mdpi.com/1660-3397/2/1/1