%0 Journal Article
%T Lyngbyastatins 8每10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena
%A Jason C. Kwan
%A Kanchan Taori
%A Valerie J. Paul
%A Hendrik Luesch
%J Marine Drugs
%D 2009
%I MDPI AG
%R 10.3390/md7040528
%X Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8每10 (1每3). The structures of 1每3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1每3 are closely related to lyngbyastatins 4每7. Like the latter compounds, we found 1每3 to inhibit porcine pancreatic elastase, with IC50 values of 123 nM, 210 nM and 120 nM, respectively.
%K lyngbyastatins
%K cyanobacteria
%K Lyngbya semiplena
%K cyclic depsipeptides
%K elastase inhibitors
%U http://www.mdpi.com/1660-3397/7/4/528