%0 Journal Article
%T 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
%A Makoto N. Masuno
%A Alexander C. Hoepker
%A Isaac N. Pessah
%A Tadeusz F. Molinski
%J Marine Drugs
%D 2004
%I MDPI AG
%R 10.3390/md204176
%X Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and ¨C2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2¦ÌM).
%K Bromotyrosine
%K calcium channel
%K Porifera
%K ryanodine receptor
%U http://www.mdpi.com/1660-3397/2/4/176