%0 Journal Article
%T Drug Release Mechanism of BSA-loaded Electrospun Fibers by AFM<br>用AFM研究静电纺丝负载药物的缓释机制
%A XU Peng
%A LI Wei
%A ZHOU Hua-cong
%A LIU Hui-zhou
%A <br>徐芃
%A 李伟
%A 周华从
%A 刘会洲
%J 过程工程学报
%D 2012
%I 
%X Experiments were carried out to study the drug delivery mechanism of bovine serum albumin(BSA) loaded chitosan(CS)-poly(ethylene oxide)(PEO) nanofibers and poly(L-lactic acid)(PLA)-CS nanofibers.Atomic force microscope(AFM) was used to observe the degradation and swelling behavior of fibers in PBS solution.As seen from the SEM images of scaffolds and drug release profiles,their BSA delivery mechanisms were different.96% BSA was released from CS-PEO nanofibers after 10 h and the structure was almost totally degraded in 1 d.AFM images showed a distinct degradation process of CS-PEO fiber and fiber diameter increasing from 0.727 to 1.43 μm from 10 to 120 min.So BSA releasing was mainly controlled by the rapid degradation of CS-PEO fibers.On the contrary,no obvious degradation was observed in the AFM or SEM images of PLA-CS nanofibers.The fiber diameter increased from 1.9 to 2.8 μm from 1 to 30 d,and the amount of BSA in solution was less than 50%.It demonstrated that the BSA delivery of PLA-CS fibers depended on the drug diffusion process.
%K atomic force microscope
%K electrospinning
%K controlled drug release
%K bovine serum albumin<br>原子力显微镜
%K 静电纺丝
%K 药物缓释
%K 牛血清蛋白
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=3FCF8B1A330466D5&jid=B9EE12934D19905403D996AE65CEEEED&aid=28538CA98C3000787EE7AEA0BDBBEEB0&yid=99E9153A83D4CB11&vid=59906B3B2830C2C5&iid=CA4FD0336C81A37A&sid=EFD65B51496FB200&eid=2F56B21F91C9B05B&journal_id=1009-606X&journal_name=过程工程学报&referenced_num=0&reference_num=0