%0 Journal Article
%T Preparation of Azithromycin Ultrafine Particles with Reactive Precipitation<br>反应沉淀法制备阿奇霉素药物超微粉体
%A Jimmy Yun
%A WANG Guo-lian
%A WANG Jie-xin
%A SHEN Zhi-gang
%A GUO Fen
%A CHEN Jian-feng
%A Jimmy Yun
%A <br>王国联
%A 王洁欣
%A 沈志刚
%A 郭奋
%A 陈建峰
%A Jimmy Yun
%J 过程工程学报
%D 2007
%I 
%X Amorphous ultra-fine azithromycin (AZM) powder was prepared by a reactive precipitation method. The effects of the operation parameters, such as concentration of NaOH solution, stirring speed and time, and reaction temperature on the particle size, morphology, dispersion and yield of the products were experimentally investigated. The as-prepared particles were characterized by SEM, BET, XRD and FT-IR techniques. The dissolution rates of the ultra-fine products and commercial crude drug were also tested. The results indicated that ultra-fine AZM with a mean particle size of 413 nm could be obtained. The BET specific surface area of the micronized AZM product was about 27 times as much as that of the commercial crude drug. Furthermore, the as-prepared AZM ultra-fine particles exhibited a significantly enhanced dissolution property, compared with the raw materials.
%K reactive precipitation
%K azithromycin
%K ultra-fine particles
%K amorphous
%K dissolution rate<br>反应沉淀
%K 阿奇霉素
%K 超微粉体
%K 无定型
%K 溶出速率
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=3FCF8B1A330466D5&jid=B9EE12934D19905403D996AE65CEEEED&aid=CF01FEE13A4E53EA87CBDAE810B5C4D4&yid=A732AF04DDA03BB3&vid=DF92D298D3FF1E6E&iid=E158A972A605785F&sid=4AB2A4AB67F2B16E&eid=EDAEFEDAC1DCCBA4&journal_id=1009-606X&journal_name=过程工程学报&referenced_num=3&reference_num=17