%0 Journal Article
%T Storage Stability of Alpha-Lipoic Acid-loaded Lipid Nanoparticles
%A TANG Jin-guo
%A XIA Qiang
%A LIU Guang-yu
%A <br>唐金国
%A 夏强
%A 刘光煜
%J 过程工程学报
%D 2010
%I 
%X Alpha-lipoic acid-loaded lipid nanoparticles (ALA-LNs) were prepared by high pressure homogenization method. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of ALA-LNs were studied in details. The stability was evaluated by particle size and polydispersity index, morphology of ALA-LNs, and capacity of ALA loading. The dilution and pH stability of ALA-LNs suspensions were also studied. After three months storage, the mean size of ALA-LNs at 4 and 40℃ was increased by 2.68% and 3.62% compared with the original size, respectively. ALA-LNs stored at 40℃ had ellipsoid shape and the mean size was about 152 nm (SD=23.6). The loading capacity of ALA at 40℃ was much higher than those stored at other two temperatures. The good dilution and pH stability were also demonstrated. The sample had good fluidity even at 4℃.
%K alpha-lipoic acid
%K lipid nanoparticles
%K storage stability
%K particle size
%K particle morphology<br>alpha-lipoic
%K acid
%K lipid
%K nanoparticles
%K storage
%K stability
%K particle
%K size
%K particle
%K morphology
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=3FCF8B1A330466D5&jid=B9EE12934D19905403D996AE65CEEEED&aid=C55F5E30C7ADF70F4731946DD98B1999&yid=140ECF96957D60B2&vid=F3090AE9B60B7ED1&iid=0B39A22176CE99FB&sid=2E01F39B6CBD53DE&eid=302684F6FB4B24FF&journal_id=1009-606X&journal_name=过程工程学报&referenced_num=0&reference_num=22