%0 Journal Article
%T Chitosan-based Intelligent Charge-reversed System for High Efficiency Delivery of Paclitaxel<br>以壳聚糖为基质的智能电荷翻转体系用于紫杉醇的高效输送
%A MA Yu-feng
%A LV Pi-ping
%A YUE Zhan-guo
%A WEI Wei
%A MA Guang-hui
%A YU Rong
%A <br>马宇峰
%A 吕丕平
%A 岳占国
%A 魏炜
%A 马光辉
%A 余蓉
%J 过程工程学报
%D 2012
%I 
%X After modification by tris(2-aminoethyl) amine(TAEA) and 2,3-dimethylmaleic anhydride(DMMA),chitosan nanoparticles(CNP) were endowed with intelligent charge-reversal ability.The fabricated system(CNP-TAEA-DMMA-nanoparticles) was then loaded with insoluble anticancer drug paclitaxel(PTX),and the drug delivery efficiency was tested in vivo.The results showed that PTX-CNP-TAEA-DMMA-nanoparticles were negatively charged(-11 mV) at normal tissue circumstance(pH 7.4) and rarely internalized by J774.1 cells,exhibiting stealth effect to macrophages.Once reaching the cancer site,those nanoparticles could intelligently transform to positive charge(+5 mV) by the low-pH microenvironment in tumor tissue,which could improve tumor cell uptake and accordingly increase the drug concentration at the lesion site.Compared with commercial PTX formulation,the nanoparticles possessed superior biocompatibility and better cytotoxicity(the value of half inhibitory concentration was decreased to 4.09 from 11.3 μg/mL),holding a great potential as efficient anti-cancer drug carrier.
%K charge reversal
%K paclitaxel
%K drug carrier
%K chitosan nanoparticle<br>电荷翻转
%K 紫杉醇
%K 药物载体
%K 壳聚糖纳米球
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=3FCF8B1A330466D5&jid=B9EE12934D19905403D996AE65CEEEED&aid=ACE46FDFF1576C2488AE0C018563A369&yid=99E9153A83D4CB11&vid=59906B3B2830C2C5&iid=38B194292C032A66&sid=E0172F1A638CE984&eid=BC88D6B0750E09D1&journal_id=1009-606X&journal_name=过程工程学报&referenced_num=0&reference_num=0