%0 Journal Article
%T Construction of Colon-specific Drug Delivery System with pH-dependency 5-ASA Using Grafted CPVA-g-PSSS Microspheres<br>由CPVA-g-PSSS功能接枝微球构建pH依赖型5-ASA结肠定位释药体系
%A MEN Ji-ying
%A GAO Bao-jiao
%A YAO Lan
%A ZHANG Yan-yan
%A <br>门吉英
%A 高保娇
%A 么兰
%A 张妍妍
%J 过程工程学报
%D 2012
%I 
%X The graft-polymerization of sodium 4-styrene sulfonate(SSS) was performed on the surface of crosslinked polyvinyl alcohol(CPVA) microspheres with cerium salt-hydroxyl group redox initiation system,the grafted CPVA-g-PSSS microspheres with strong anionic polyelectrolyte PSSS were obtained.On this basis,the adsorption property of the microspheres for 5-amino salicylic acid(5-ASA),namely drug carrying ability,was investigated and the adsorption mechanism analyzed.The in vitro release behavior of the drug-carried microspheres was also examined.The experimental results show that the grafted CPVA-g-PSSS microspheres exhibit very strong adsorption ability for 5-ASA by driving of electrostatic interaction in the acidic medium.Their adsorption capacity can reach 39.1 mg/g,displaying a high efficiency of drug-loading.Their in vitro release behavior is highly pH-dependent.In the medium of pH=1,the drug is not released,while in that of pH=7.4,the burst release occurs,displaying an excellent colon-specific drug delivery behavior.
%K sodium 4-styrene sulfonate
%K crosslinked polyvinyl alcohol microspheres
%K graft polymerization
%K 5-amino salicylic acid
%K pH-dependence
%K colon-specific drug delivery<br>对苯乙烯磺酸钠
%K 交联聚乙烯醇微球
%K 接枝聚合
%K 5-氨基水杨酸
%K pH依赖性
%K 结肠定位释放
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=3FCF8B1A330466D5&jid=B9EE12934D19905403D996AE65CEEEED&aid=21CB0722CA48644F2D92C59D4D1391A5&yid=99E9153A83D4CB11&vid=59906B3B2830C2C5&iid=E158A972A605785F&sid=36C49E1242CC2C7A&eid=66D0A4667FE1A38D&journal_id=1009-606X&journal_name=过程工程学报&referenced_num=0&reference_num=0