%0 Journal Article %T Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples %A B¨¦atrice Roy %A Sung Vo Duy %A Jean-Yves Puy %A Charlotte Martin %A J¨¦rome Guitton %A Charles Dumontet %A Christian P¨¦rigaud %A Isabelle Lefebvre-Tournier %J Journal of Functional Biomaterials %D 2012 %I MDPI AG %R 10.3390/jfb3010131 %X A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 ¦Ìmol£¿g£¿1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples. %K molecularly imprinted polymer %K irinotecan %K human serum %K LC-PDA %U http://www.mdpi.com/2079-4983/3/1/131