%0 Journal Article
%T New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
%A Waqar Ahmad Kaleem
%A Muhammad Nisar
%A Mughal Qayum
%A Muhammad Zia-Ul-Haq
%A Achyut Adhikari
%A Vincenzo De Feo
%J International Journal of Molecular Sciences
%D 2012
%I MDPI AG
%R 10.3390/ijms130911520
%X Two new 14-membered cyclopeptide alkaloids, Oxyphylline B ( 4) and Oxyphylline C ( 5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B ( 4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 ¦Ìg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 ¦Ìg/mL), Pseudomonas aeruginosa (MIC, 50 ¦Ìg/mL) and Salmonella typhi (MIC, 50 ¦Ìg/mL).
%K Zizyphus oxyphylla Edgew
%K cyclopeptide alkaloids
%K antibacterial activity
%U http://www.mdpi.com/1422-0067/13/9/11520