%0 Journal Article
%T Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways
%A Kentaro Nakayama
%A Naomi Nakayama
%A Hiroshi Katagiri
%A Kohji Miyazaki
%J International Journal of Molecular Sciences
%D 2012
%I MDPI AG
%R 10.3390/ijms130911705
%X Ovarian cancer is the most lethal gynecologic malignancy. Despite advances in chemotherapy, the five-year survival rate of advanced ovarian cancer patients with peritoneal metastasis remains around 30%. The most significant prognostic factor is stage, and most patients present at an advanced stage with peritoneal dissemination. There is often no clearly identifiable precursor lesion; therefore, the events leading to metastatic disease are poorly understood. This article reviews metastatic suppressor genes, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment as they relate to ovarian cancer metastasis. Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed.
%K cancer
%K metastasis suppressor gene
%K EMT
%K tumor microenvironment
%U http://www.mdpi.com/1422-0067/13/9/11705