%0 Journal Article
%T Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
%A Zhenting Du
%A Changmei Si
%A Youqiang Li
%A Yin Wang
%A Jing Lu
%J International Journal of Molecular Sciences
%D 2012
%I MDPI AG
%R 10.3390/ijms13044696
%X A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1 H-tetrazoles is described. The protocol can provide a series of 5-substituted 1 H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%¨C95% yield.
%K silica sulfuric acid
%K 5-substituted 1H-tetrazoles
%K [3+2] cycloaddition
%U http://www.mdpi.com/1422-0067/13/4/4696