%0 Journal Article
%T The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
%A Jing Wang
%A Hong Lu
%A Yingzhi Xu
%A Xiaofeng Hu
%A Wei Chen
%A Shang Li
%J International Journal of Molecular Sciences
%D 2012
%I MDPI AG
%R 10.3390/ijms13022110
%X In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-¦ĘB (NF-¦ĘB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
%K Toll-like receptor 4
%K Cytokine
%K cytometric bead array technology
%K aqueous humor
%K Anterior Uveitis
%U http://www.mdpi.com/1422-0067/13/2/2110