%0 Journal Article
%T Inhibition Effect of IL-1β on Calcium Channels Currents in Cultured Cortical Neurons of Rat<br>白介素1β对培养的大鼠皮层神经元钙通道电流的抑制作用
%A ZHOU Chen
%A <br>周辰
%J 动物学研究
%D 2010
%I Chinese Academy of Sciences
%X Interleukin-1β(IL-1β) is an important porinflammatory cytokine that exert wide biological functions in the central nervous system (CNS). Voltage-gated Ca~(2+) channels in plasma membrane axe essential components of Ca~(2+) signal whose change on pathological conditions is closely related to processes of diseases. Although both IL-1βand Ca~(2+)channels have key roles in injury and disease of the brain, so far their relations have been reported in few studies. The effects of IL-1βon Ca~(2+) channels in cultured cortical neurons of rats were investigated using patch-clamp recording in present research. Our results showed that both 10 and 50 ng/mL of IL-1βtreatment inhibit the Ca~(2+) currents in time and dose dependent manner, without the change of activation properties of voltage-gated Ca~(2+) channels (VGCC)s.
%K Ca~(2+) currents
%K Patch-clamp recording
%K Cortical neurons<br>白介素1β
%K 钙电流
%K 膜片钳记录
%K 皮层神经元
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=4719B38D05B85C09B68360242927FCC0&yid=140ECF96957D60B2&vid=4AD960B5AD2D111A&iid=CA4FD0336C81A37A&sid=CFAC5CB624A41AFD&eid=39EEF47180459690&journal_id=0254-5853&journal_name=动物学研究&referenced_num=1&reference_num=22