%0 Journal Article
%T Homology Modeling and Molecular Evolution Analysis of Myostatin<br>Myostatin三维结构模建及分子进化分析
%A XIE Yu-wei
%A XUE Xiao-ping
%A YIN Huan-cai
%A TANG Rui-hua
%A SU Jing
%A SONG Kai
%A HUYAN Ting
%A WANG Hua
%A YANG Hui
%A <br>谢玉为
%A 薛小平
%A 尹焕才
%A 唐蕊华
%A 苏 婧
%A 宋 凯
%A 呼延霆
%A 汪 桦
%A 杨 慧
%J 动物学研究
%D 2008
%I Chinese Academy of Sciences
%X Myostatin(MST) is the cytokine negatively regulated skeletal muscle growth factor, and the loss of function caused by mutations is associated with increased skeletal muscle mass.The multiple sequence alignment of the available MST cDNA sequences and the related evolutionary analyses were performed;the quarternary structures of MST homodimer and the MST:ActRIIB complex was built using homology modelling technique.The phylogenetic tree revealed that there were four sub-families, i.e., mammalian MSTN, avian MSTN, and fish MSTN1, 2 in the MST gene(MSTN) family.MST orthologous genes derived from different species had a high sequence identity, which were probably caused by the purifying selection.Particularly, the high degree of conservation of C-terminal sequences of mammalian and avian MST mature peptides suggested they shared the very similar structure, function and signal transduction pathway.The analyses of electrostatic potential and hydrophobic amino acid distribution of the structural models revealed that the electrostatic force and hydrophobic interaction played an important role in receptor recognition by MST.
%K Myostatin
%K Molecular evolution
%K Homology modeling<br>肌肉生长抑制素基因
%K 分子进化
%K 同源模建
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=2B2E186C312CA81EBAEF75E3EAB41E60&yid=67289AFF6305E306&vid=771469D9D58C34FF&iid=94C357A881DFC066&sid=5CB576B96D187F64&eid=4A2356A1257A12EB&journal_id=0254-5853&journal_name=动物学研究&referenced_num=1&reference_num=15