%0 Journal Article
%T Research Advances in Growth Hormone Receptor<br>生长激素受体的研究进展
%A DENG Li
%A ZHANG Wei
%A Min
%A LIN Hao
%A Ran
%A <br>邓利
%A 张为民
%J 动物学研究
%D 2001
%I Chinese Academy of Sciences
%X Pituitary growth hormone (GH) is essential for growth and metabolism in animals.Association of GH with the GH receptor (GHR) in target tissues of GH triggers the postreceptor signaling systems,which culminate in the biological actions of GH.GHR is a glycoprotein of about 620 amino acids (aa) with single transmembrane domain.The extracellular,the transmembrane and the intracellular domain of GHR are composed of about 245aa,25aa and 350aa respectively.The pathways of signaling by GHR include the activations of the tyrosine kinase JAK2,the protein kinase C and the insulin receptor substrate.Nutrition,GH and other factors can also regulate the expression of GHR.
%K Growth hormone receptor
%K Signal transduction
%K Regulation<br>生长激素受体
%K 信号转导
%K 调节
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=CBFED8BE518239DD&yid=14E7EF987E4155E6&vid=BC12EA701C895178&iid=38B194292C032A66&sid=6ED15D8DCB279BC4&eid=D6354F61445E9456&journal_id=0254-5853&journal_name=动物学研究&referenced_num=5&reference_num=25