%0 Journal Article
%T AN EVALUATION OF SECURITY FOR KINGPANAX FRESH Panax notoginseng JUICE IN MUTAGENIC AND TERATOGENIC TESTS OF MAMMAL<br>金不换鲜三七液对哺乳动物致突变和致畸安全性评价
%A ZHENG Wen-kang
%A ZHANG Yun-sheng
%A HE Wei-shun
%A LIU Ai-hua
%A WANG Rui-fang
%A LIN Shi-ying
%A HOU Yi-di
%A <br>郑文康
%A 张云生 有限公司
%A 昆明
%A 贺维顺
%A 刘爱华
%A 王蕊芳
%A 林世英
%A 侯意谛
%J 动物学研究
%D 1999
%I Chinese Academy of Sciences
%X This paper was to investigate the mutagenicity of KINGPANAX fresh Panax notoginseng juice.We used chromosomal aberration test of bone marrow cells in mice,chromosomal aberration test in mouse testicle meiotic cells and teratogenicity test in mice as an indicater to study the securities of KINGPANAX fresh Panax notoginseng juice.The results were as follows:(a) Chromosomal aberration of bone marrow in mice:Frequency of chromosomal aberration of bone marrow in mice in the control group was 0 8%,the frequencies of low,middle and high dose groups were 0 7%,0 2% and 0 9% respectively.In comparison with control group,there was no significant difference,More significant increase of frequency of chromosomal aberration were found in positive control group.(b) Chromosomal aberration in mouse testicle meiotic cells:Under our experimental conditions,frequency of chromosomal aberration in mouse testicle meiotic cells (including sex chromosomal univalents X-YU],autosomal univalents AU] showed no obvious difference among various experimental groups and control group.(c) Teratogenicity test in mice:The accumulative doses of KINGPANAX fresh Panax notoginseng juice in mice by gastric instillation reached 1/10,1/5 and 1/2 of 15?g/kg body weight.No statistically significant difference in the mouse teratogenicity test was observed.According to our exparimental results,KINGPANAX fresh Panax notoginseng juice is safe for drinking and has no poisonous side effect.
%K KINGPANAX fresh
%K Panax notoginseng
%K juice
%K Evaluation of security
%K Bone marrow cells
%K Mouse testicle cells
%K Chromosomal aberration
%K Teratogenicity test in mice<br>金不换鲜三七液
%K 安全性评价
%K 骨髓细胞
%K 睾丸细胞
%K 染色体畸变
%K 小鼠致畸试验
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=822A5EB2400808E0&yid=B914830F5B1D1078&vid=A04140E723CB732E&iid=94C357A881DFC066&sid=4AD4BA66429F5627&eid=377D325742940769&journal_id=0254-5853&journal_name=动物学研究&referenced_num=1&reference_num=12