%0 Journal Article
%T Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins<br>核糖体失活蛋白抗HIV-1作用的研究进展
%A WANG Jian-hua
%A OUYANG Dong-yun
%A WANG Yuan-yuan
%A ZHENG Yong-tang
%A <br>王建华
%J 动物学研究
%D 2006
%I Chinese Academy of Sciences
%X The anti-HIV-1 research history of ribosome inactivating proteins (RIPs) can be traced back to McGrath's work in 1989. They are important representatives, which guide further research, of natural anti-HIV products or leading compounds. The enzymatic activities and anti-HIV-1 actions of RIPs were introduced initially in this paper, followed by a detailed discussion about the potential anti-HIV-1 mechanisms. The discussion mainly focuses on the relationships with anti-HIV-1 enzymatic activities, induction of apoptosis of HIV-1 infected cells and responding cell signaling, the production of reactive oxygen species, the HIV-1 integrase inhibition effect. The anti-HIV-1 structure-functional relationship of RIPs and the structural modifications were also covered. Systemic and intensive studies of RIPs' antiviral actions will increase their possibility as clinical anti-HIV/AIDS agents.
%K Ribosome inactivating protein
%K Trichosanthin
%K RNA-N Glycosidase
%K Antiviral mechanism
%K HIV-1<br>核糖体失活蛋白
%K 天花粉蛋白
%K RNA-N糖苷酶
%K 抗病毒机制
%K HIV-1
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=11EABEA19E1A44DE&yid=37904DC365DD7266&vid=DB817633AA4F79B9&iid=94C357A881DFC066&sid=1918ADDC93A85779&eid=E5D85F291CED2DA6&journal_id=0254-5853&journal_name=动物学研究&referenced_num=0&reference_num=56