%0 Journal Article
%T STUDIES ON THE THROMBIN-LIKE PRINCIPLES OF Agkistrodon acutus VENOM III. STUDIES ON HEMOSTATIC EFFECT OF HEMOCOAGULASE<br>尖吻蝮(Agkistrodon acutus)蛇毒凝血酶样成分的研究——Ⅲ.蛇毒凝血酶止血效应的研究
%A He Lifeng Xiao Changhua Dong Fuming Yang Lianxi
%A <br>何丽芬
%A 肖昌华
%A 董馥明
%A 杨连玺
%J 动物学研究
%D 1990
%I Chinese Academy of Sciences
%X Thrombin-like enzymes (TLE3, TLE4) had been isolated and purified from the venom of Agkistrodon acutus. With 2- 3 NIH units/kg in vivo the result showed that the blood coagulation time of rabbits was shortened in 1/3-1/2. In vivo eyperiments (2NIH or 3NIH/kg) after 1 hr TLE began to show effect, after 2 - 4 hr the effect was most strong, after 12 hr there was no effect. The properties of TLE is similar to hemocoagulase from venom Bathrope jararaca. The experiments showed that TLE 3 and 4 of A. acutus can used as hemostatic agents.
%K Thrombin-like enzyones (TLE)
%K Hemocoagulase
%K Hcmostasis
%K Hemostatic drug<br>凝血酶样酶
%K 蛇毒凝血酶
%K 止血效应
%K 止血药
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=4B52D29BCA9ECA42&yid=8D39DA2CB9F38FD0&vid=708DD6B15D2464E8&iid=E158A972A605785F&sid=717CC18E05F2AFA0&eid=B66C5792F4740920&journal_id=0254-5853&journal_name=动物学研究&referenced_num=0&reference_num=0