%0 Journal Article
%T Novel Neuroprotective Strategies in Ischemic Retinal Lesions
%A Krisztina Szabadfi
%A Laszlo Mester
%A Dora Reglodi
%A Peter Kiss
%A Norbert Babai
%A Boglarka Racz
%A Krisztina Kovacs
%A Aliz Szabo
%A Andrea Tamas
%A Robert Gabriel
%A Tamas Atlasz
%J International Journal of Molecular Sciences
%D 2010
%I MDPI AG
%R 10.3390/ijms11020544
%X Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K + channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
%K BCCAO
%K ischemia
%K retinoprotection
%K urocortin 2
%K diazoxide
%K PACAP
%K PARP-inhibitor
%K rat retina
%U http://www.mdpi.com/1422-0067/11/2/544