%0 Journal Article
%T Nuclear Translocation of Nuclear Factor Kappa B in First Trimester Deciduas and Chorionic Villi in Early Spontaneous Miscarriage Women
%A Li-qin Wang
%A Xue-wen Yu
%A Chun-fang Yan
%A Xiang Wang
%J International Journal of Molecular Sciences
%D 2010
%I MDPI AG
%R 10.3390/ijms11020521
%X The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.
%K early spontaneous miscarriage
%K nuclear factor kappa B
%K confocal laser scanning microscope
%K immunohistochemistry
%U http://www.mdpi.com/1422-0067/11/2/521