%0 Journal Article
%T A mathematical model of a P53 oscillation network triggered by DNA damage<br>
%A Xia Jun-Feng
%A Jia Ya
%A <br>
%J 中国物理 B
%D 2010
%I 
%X Taking the interaction between a DNA damage repair module, an ATM module, and a P53--MDM2 oscillation module into account, this paper presents a mathematical model of a P53 oscillation network triggered by a DNA damage signal in individual cells. The effects of the DNA damage signal and the delay time of P53-induced MDM2 expression on the behaviours of the P53 oscillation network are studied. In the oscillatory state of the P53--MDM2 oscillator, it is found that the pulse number of P53--P oscillation increases with the increase of the initial DNA damage signal, whereas the amplitude and the period of P53--P oscillation are fixed for different initial DNA damage signals, and the period numbers of P53--P oscillations decrease with the increase of time delay of MDM2 expression induced by P53. These theoretical predictions are consistent with previous experimental results. The combined negative feedback of P53--MDM2 with the time delay of P53-induced MDM2 expression causes oscillation behaviour in the P53 network.
%K P53 oscillation network
%K DNA damage signal
%K time delay
%K kinetic model<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=CD8D6A6897B9334F09D8D1648C376FB4&aid=5C0CCB7B32A6A9FCC26ABF561920F68C&yid=140ECF96957D60B2&vid=2A8D03AD8076A2E3&iid=E158A972A605785F&journal_id=1009-1963&journal_name=中国物理&referenced_num=0&reference_num=20