%0 Journal Article
%T Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy
%A Massimiliano Balbi
%A Valter Donadon
%A Michela Ghersetti
%A Silvia Grazioli
%A Giovanni Della Valentina
%A Rita Gardenal
%A Maria Dal Mas
%A Pietro Casarin
%A Giorgio Zanette
%A Cesare Miranda
%A Paolo Cimarosti
%J International Journal of Environmental Research and Public Health
%D 2010
%I MDPI AG
%R 10.3390/ijerph7041366
%X Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.
%K Hepatocellular carcinoma
%K Type 2 diabetes mellitus
%K HCV infections
%K alcohol abuse
%U http://www.mdpi.com/1660-4601/7/4/1366