%0 Journal Article
%T Progress in vaccine development of hepatitis C virus infection<br>丙型肝炎病毒（HCV）实验性疫苗的研究进展
%A TAN Wen-jie
%A ZHANG Ke
%A RUAN Li
%A <br>谭文杰
%A 张柯
%A 阮力
%J 中国生物工程杂志
%D 2006
%I 
%X Hepatitis C virus (HCV) accounts for the majority of cases of transfusion acquired hepatitis and may cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine against HCV and treatment is expensive and not always effective.The adaptive host immune response in viral clearance of HCV infection was described and the recent progress in vaccine development of HCV, focusing on the fields of DNA vaccine candidates, recombinant viral vectored vaccine candidates and combined (prime-boost) vaccine candidates were summarized. Some challenges and limitations of developing a HCV vaccine were also analysed. In summary, a promising approach of developing an experimental HCV vaccine to induce extremely potent and broad T-cell responses based on prime-boost strategy was presented.
%K Hepatitis C virus DNA vaccine Recombinant viral vector vaccine Prime-boost strategy<br>丙型肝炎病毒
%K DNA疫苗
%K 病毒载体疫苗
%K 初免-加强免疫策略
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=FEB7A6597F275B4E&yid=37904DC365DD7266&vid=96C778EE049EE47D&iid=F3090AE9B60B7ED1&sid=95D537AC89B28832&eid=68D88C2FCF9C3098&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=1&reference_num=40