%0 Journal Article
%T Multiple Roles of Antimicrobial Peptides in Host Denfence<br>抗菌肽在宿主防御中作用
%A SHI Chun-Lin
%A <br>史春林
%A 王云峰
%A 石星明
%A 王玫
%A 孙妍
%A 童光志
%J 中国生物工程杂志
%D 2008
%I 
%X Cationic antimicrobial peptides are produced by all organisms, from plants and insects to human beings, as a major part of their immediately effective, nonspecific defences against infections. Although many demonstrate direct antimicrobial activity against bacteria, fungi, eukaryotic parasites and/or viruses, it has been established that antimicrobial peptides have a key modulatory role in the interface of innate and adaptive immunity. More recent evidence suggests that antimicrobial peptides are effective adjuvants, are synergistic with other immune effectors, initiate the adaptive response, support wound healing, induce or modulate of chemokine and cytokine production, alterate of gene expression in host cells, and inhibit of proinflammatory responses of host cells.In addition, the mechanisms of action are being unraveled, which support more effective implementation of derivatives of these endogenous peptides as therapeutic agents in overcoming infectious diseases.
%K Innate immunity
%K Host defence
%K Antimicrobial peptides<br>先天免疫
%K 宿主防御
%K 抗菌肽
%K 抗菌肽
%K 宿主防御
%K 作用机理
%K Host
%K Peptides
%K 前景
%K 应用
%K 药剂
%K 抗感染治疗
%K 衍生物
%K 内源性
%K 趋化因子
%K 细胞因子
%K 调节作用
%K 炎症反应
%K 伤口愈合
%K 协同作用
%K 免疫效应
%K 辅助因子
%K 证据
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=551F4FAE51E093A89D6A3241DF37A3FD&yid=67289AFF6305E306&vid=D3E34374A0D77D7F&iid=E158A972A605785F&sid=0D0D661F0B316AD5&eid=CD775AE9DDBD7B53&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=22