%0 Journal Article
%T Studies on sLea/x and hematogenous metastasis of cancer<br>sLea/x与肿瘤血源性转移研究进展
%A PENG Yun-li
%A LI Jing
%A GENG Mei-yu
%A <br>彭云丽
%A 李静
%A 耿美玉
%J 中国生物工程杂志
%D 2007
%I 
%X The expression of sLea/x which correlates with conventional histopathologic parameters serves as a useful indicator for the prognosis of metastatic disease. The bindings between sLea/x and their common ligand E-selectin initiate hematogenous metastasis of cancer. Certain bioactive conformation is crucial for the interaction between sLea/x and their ligands. Thus, a new class of compounds that mimic the structures of sLea/x can potently inhibit not only their functional bindings to selectins, but also the metastasis of cancer. This review is mainly on the sLea/x molecular structure,biosynthesis,distribution, especially the relationship between sLea/x and hematogenous metastasis of cancer and the design of drugs that mimic the structures of sLea/x.
%K sLe~(a/x) Cancer Hematogenous metastasis Bioactive conformation<br>sLea/x
%K 肿瘤
%K 血源性转移
%K 活性构象
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=C7F24C76CA7FBE1B&yid=A732AF04DDA03BB3&vid=DB817633AA4F79B9&iid=B31275AF3241DB2D&sid=08805F9252973BA4&eid=C36EC077A8A90308&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=19